Withaferin A Alters Intermediate Filament Organization, Cell Shape and Behavior

Withaferin A (WFA) is a steroidal lactone present in Withania somnifera which has been shown in vitro to bind to the intermediate filament protein, vimentin. Based upon its affinity for vimentin, it has been proposed that WFA can be used as an anti-tumor agent to target metastatic cells which up-reg...

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Detalles Bibliográficos
Autores principales: Grin, Boris, Mahammad, Saleemulla, Wedig, Tatjana, Cleland, Megan M., Tsai, Lester, Herrmann, Harald, Goldman, Robert D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376126/
https://www.ncbi.nlm.nih.gov/pubmed/22720028
http://dx.doi.org/10.1371/journal.pone.0039065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376126/
https://www.ncbi.nlm.nih.gov/pubmed/22720028
http://dx.doi.org/10.1371/journal.pone.0039065

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