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Withaferin A Alters Intermediate Filament Organization, Cell Shape and Behavior
Withaferin A (WFA) is a steroidal lactone present in Withania somnifera which has been shown in vitro to bind to the intermediate filament protein, vimentin. Based upon its affinity for vimentin, it has been proposed that WFA can be used as an anti-tumor agent to target metastatic cells which up-reg...
Autores principales: | Grin, Boris, Mahammad, Saleemulla, Wedig, Tatjana, Cleland, Megan M., Tsai, Lester, Herrmann, Harald, Goldman, Robert D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376126/ https://www.ncbi.nlm.nih.gov/pubmed/22720028 http://dx.doi.org/10.1371/journal.pone.0039065 |
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