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Deletion of the epidermal growth factor receptor in renal proximal tubule epithelial cells delays recovery from acute kidney injury

To determine the role of epidermal growth factor receptor (EGFR) activation in renal functional and structural recovery from acute kidney injury (AKI), we generated mice with a specific EGFR deletion in the renal proximal tubule (EGFR(ptKO)). Ischemia–reperfusion injury markedly activated EGFR in co...

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Detalles Bibliográficos
Autores principales: Chen, Jianchun, Chen, Jian-Kang, Harris, Raymond C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376190/
https://www.ncbi.nlm.nih.gov/pubmed/22418982
http://dx.doi.org/10.1038/ki.2012.43