Gene Set Enrichment Analysis Identifies LIF as a Negative Regulator of Human Th2 Cell Differentiation

In this study we show that IL-4 is crucial during reinforcement window of human Th2 differentiation for optimal Th2 development. We have also shown here that during this stage, IL-4 helps in cellular decision-making process of differentiation versus proliferation. We have combined computational and...

Descripción completa

Detalles Bibliográficos
Autores principales: Ullah, Ubaid, Tripathi, Parul, Lahesmaa, Riitta, Rao, Kanury V. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376453/
https://www.ncbi.nlm.nih.gov/pubmed/22712053
http://dx.doi.org/10.1038/srep00464
_version_ 1782235827482394624
author Ullah, Ubaid
Tripathi, Parul
Lahesmaa, Riitta
Rao, Kanury V. S.
author_facet Ullah, Ubaid
Tripathi, Parul
Lahesmaa, Riitta
Rao, Kanury V. S.
author_sort Ullah, Ubaid
collection PubMed
description In this study we show that IL-4 is crucial during reinforcement window of human Th2 differentiation for optimal Th2 development. We have also shown here that during this stage, IL-4 helps in cellular decision-making process of differentiation versus proliferation. We have combined computational and experimental methods to analyze Th2 transcription network to name novel players of the process of Th2 differentiation. Here we report that LIF through STAT3 negatively regulates Th2 differentiation. This approach can be generalized to analyze “omics” data to identify key regulatory modules.
format Online
Article
Text
id pubmed-3376453
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-33764532012-06-18 Gene Set Enrichment Analysis Identifies LIF as a Negative Regulator of Human Th2 Cell Differentiation Ullah, Ubaid Tripathi, Parul Lahesmaa, Riitta Rao, Kanury V. S. Sci Rep Article In this study we show that IL-4 is crucial during reinforcement window of human Th2 differentiation for optimal Th2 development. We have also shown here that during this stage, IL-4 helps in cellular decision-making process of differentiation versus proliferation. We have combined computational and experimental methods to analyze Th2 transcription network to name novel players of the process of Th2 differentiation. Here we report that LIF through STAT3 negatively regulates Th2 differentiation. This approach can be generalized to analyze “omics” data to identify key regulatory modules. Nature Publishing Group 2012-06-18 /pmc/articles/PMC3376453/ /pubmed/22712053 http://dx.doi.org/10.1038/srep00464 Text en Copyright © 2012, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Article
Ullah, Ubaid
Tripathi, Parul
Lahesmaa, Riitta
Rao, Kanury V. S.
Gene Set Enrichment Analysis Identifies LIF as a Negative Regulator of Human Th2 Cell Differentiation
title Gene Set Enrichment Analysis Identifies LIF as a Negative Regulator of Human Th2 Cell Differentiation
title_full Gene Set Enrichment Analysis Identifies LIF as a Negative Regulator of Human Th2 Cell Differentiation
title_fullStr Gene Set Enrichment Analysis Identifies LIF as a Negative Regulator of Human Th2 Cell Differentiation
title_full_unstemmed Gene Set Enrichment Analysis Identifies LIF as a Negative Regulator of Human Th2 Cell Differentiation
title_short Gene Set Enrichment Analysis Identifies LIF as a Negative Regulator of Human Th2 Cell Differentiation
title_sort gene set enrichment analysis identifies lif as a negative regulator of human th2 cell differentiation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376453/
https://www.ncbi.nlm.nih.gov/pubmed/22712053
http://dx.doi.org/10.1038/srep00464
work_keys_str_mv AT ullahubaid genesetenrichmentanalysisidentifieslifasanegativeregulatorofhumanth2celldifferentiation
AT tripathiparul genesetenrichmentanalysisidentifieslifasanegativeregulatorofhumanth2celldifferentiation
AT lahesmaariitta genesetenrichmentanalysisidentifieslifasanegativeregulatorofhumanth2celldifferentiation
AT raokanuryvs genesetenrichmentanalysisidentifieslifasanegativeregulatorofhumanth2celldifferentiation

Ejemplares similares