Crystal structure of Caulobacter crescentus polynucleotide phosphorylase reveals a mechanism of RNA substrate channelling and RNA degradosome assembly

Polynucleotide phosphorylase (PNPase) is an exoribonuclease that cleaves single-stranded RNA substrates with 3′–5′ directionality and processive behaviour. Its ring-like, trimeric architecture creates a central channel where phosphorolytic active sites reside. One face of the ring is decorated with...

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Detalles Bibliográficos
Autores principales: Hardwick, Steven W., Gubbey, Tobias, Hug, Isabelle, Jenal, Urs, Luisi, Ben F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376730/
https://www.ncbi.nlm.nih.gov/pubmed/22724061
http://dx.doi.org/10.1098/rsob.120028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376730/
https://www.ncbi.nlm.nih.gov/pubmed/22724061
http://dx.doi.org/10.1098/rsob.120028

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