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Crystal structure of Caulobacter crescentus polynucleotide phosphorylase reveals a mechanism of RNA substrate channelling and RNA degradosome assembly
Polynucleotide phosphorylase (PNPase) is an exoribonuclease that cleaves single-stranded RNA substrates with 3′–5′ directionality and processive behaviour. Its ring-like, trimeric architecture creates a central channel where phosphorolytic active sites reside. One face of the ring is decorated with...
Autores principales: | Hardwick, Steven W., Gubbey, Tobias, Hug, Isabelle, Jenal, Urs, Luisi, Ben F. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376730/ https://www.ncbi.nlm.nih.gov/pubmed/22724061 http://dx.doi.org/10.1098/rsob.120028 |
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