RhoB regulates cell migration through altered focal adhesion dynamics

The Rho GTPase RhoB has been shown to affect cell migration, but how it does this is not clear. Here we show that cells depleted of RhoB by RNAi are rounded and have defects in Rac-mediated spreading and lamellipodium extension, although they have active membrane ruffling around the periphery. Deple...

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Detalles Bibliográficos
Autores principales: Vega, Francisco M., Colomba, Audrey, Reymond, Nicolas, Thomas, Mairian, Ridley, Anne J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376739/
https://www.ncbi.nlm.nih.gov/pubmed/22724071
http://dx.doi.org/10.1098/rsob.120076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376739/
https://www.ncbi.nlm.nih.gov/pubmed/22724071
http://dx.doi.org/10.1098/rsob.120076

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