Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells

Histone deacetylases (HDACs) and microRNAs (miRs) have pro-survival roles, but the mechanism behind this is unclear. Repression of ceramide synthase 1 (CerS1), altering C(18)-ceramide generation, was linked to drug resistance and metastasis. Here we report that the CerS1 promoter was repressed by HD...

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Detalles Bibliográficos
Autores principales: Meyers-Needham, Marisa, Ponnusamy, Suriyan, Gencer, Salih, Jiang, Wenhui, Thomas, Raquela J, Senkal, Can E, Ogretmen, Besim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376837/
https://www.ncbi.nlm.nih.gov/pubmed/22180294
http://dx.doi.org/10.1002/emmm.201100189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376837/
https://www.ncbi.nlm.nih.gov/pubmed/22180294
http://dx.doi.org/10.1002/emmm.201100189

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