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Enhanced 15-lipoxygenase activity and elevated eicosanoid production in kidney tumor microenvironment contribute to the inflammation and immune suppression
Macrophage infiltration is a hallmark in the majority of solid tumors. Our studies demonstrated that macrophages that infiltrate human renal cells carcinoma (RCC) display markedly enhanced expression and activity of 15-lipoxygenase-2 (15-LOX2). Obtained data suggest that enhanced lipoxygenase activi...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377006/ https://www.ncbi.nlm.nih.gov/pubmed/22720260 http://dx.doi.org/10.4161/onci.1.2.18502 |