Parachuting in the epigenome: the biology of gene vector insertion profiles in the context of clinical trials

Retroviral pre-integration complexes (PICs) provide a most efficient mechanism to integrate foreign DNA into cellular chromatin. This has made retrovirus-based vectors a preferred tool for gene delivery in therapeutic settings where the chromosomal integration of a recombinant expression cassette th...

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Detalles Bibliográficos
Autor principal: Baum, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2011
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377063/
https://www.ncbi.nlm.nih.gov/pubmed/21254403
http://dx.doi.org/10.1002/emmm.201000110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377063/
https://www.ncbi.nlm.nih.gov/pubmed/21254403
http://dx.doi.org/10.1002/emmm.201000110

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