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Parachuting in the epigenome: the biology of gene vector insertion profiles in the context of clinical trials
Retroviral pre-integration complexes (PICs) provide a most efficient mechanism to integrate foreign DNA into cellular chromatin. This has made retrovirus-based vectors a preferred tool for gene delivery in therapeutic settings where the chromosomal integration of a recombinant expression cassette th...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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WILEY-VCH Verlag
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377063/ https://www.ncbi.nlm.nih.gov/pubmed/21254403 http://dx.doi.org/10.1002/emmm.201000110 |