Combined genomic and phenotype screening reveals secretory factor SPINK1 as an invasion and survival factor associated with patient prognosis in breast cancer

Secretory factors that drive cancer progression are attractive immunotherapeutic targets. We used a whole-genome data-mining approach on multiple cohorts of breast tumours annotated for clinical outcomes to discover such factors. We identified Serine protease inhibitor Kazal-type 1 (SPINK1) to be as...

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Detalles Bibliográficos
Autores principales: Soon, Wendy WeiJia, Miller, Lance David, Black, Michael A, Dalmasso, Cyril, Chan, Xiu Bin, Pang, Brendan, Ong, Chee Wee, Salto-Tellez, Manuel, Desai, Kartiki V, Liu, Edison T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377086/
https://www.ncbi.nlm.nih.gov/pubmed/21656687
http://dx.doi.org/10.1002/emmm.201100150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377086/
https://www.ncbi.nlm.nih.gov/pubmed/21656687
http://dx.doi.org/10.1002/emmm.201100150

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