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Combined genomic and phenotype screening reveals secretory factor SPINK1 as an invasion and survival factor associated with patient prognosis in breast cancer
Secretory factors that drive cancer progression are attractive immunotherapeutic targets. We used a whole-genome data-mining approach on multiple cohorts of breast tumours annotated for clinical outcomes to discover such factors. We identified Serine protease inhibitor Kazal-type 1 (SPINK1) to be as...
Autores principales: | Soon, Wendy WeiJia, Miller, Lance David, Black, Michael A, Dalmasso, Cyril, Chan, Xiu Bin, Pang, Brendan, Ong, Chee Wee, Salto-Tellez, Manuel, Desai, Kartiki V, Liu, Edison T |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
WILEY-VCH Verlag
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377086/ https://www.ncbi.nlm.nih.gov/pubmed/21656687 http://dx.doi.org/10.1002/emmm.201100150 |
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