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Oncogene addiction as a foundational rationale for targeted anti-cancer therapy: promises and perils

A decade has elapsed since the concept of oncogene addiction was first proposed. It postulates that – despite the diverse array of genetic lesions typical of cancer – some tumours rely on one single dominant oncogene for growth and survival, so that inhibition of this specific oncogene is sufficient...

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Detalles Bibliográficos
Autores principales: Torti, Davide, Trusolino, Livio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377106/
https://www.ncbi.nlm.nih.gov/pubmed/21953712
http://dx.doi.org/10.1002/emmm.201100176