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Oncogene addiction as a foundational rationale for targeted anti-cancer therapy: promises and perils
A decade has elapsed since the concept of oncogene addiction was first proposed. It postulates that – despite the diverse array of genetic lesions typical of cancer – some tumours rely on one single dominant oncogene for growth and survival, so that inhibition of this specific oncogene is sufficient...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
WILEY-VCH Verlag
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377106/ https://www.ncbi.nlm.nih.gov/pubmed/21953712 http://dx.doi.org/10.1002/emmm.201100176 |