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Acute Inducible Ablation of GRP78 Reveals Its Role in Hematopoietic Stem Cell Survival, Lymphogenesis and Regulation of Stress Signaling

GRP78, a master regulator of the unfolded protein response (UPR) and cell signaling, is required for inner cell mass survival during early embryonic development. However, little is known about its role in adult hematopoietic stem cells (HSCs) and hematopoiesis. Here we generated a conditional knocko...

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Detalles Bibliográficos
Autores principales: Wey, Shiuan, Luo, Biquan, Lee, Amy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377598/
https://www.ncbi.nlm.nih.gov/pubmed/22723926
http://dx.doi.org/10.1371/journal.pone.0039047