Sodium Phenylbutyrate Controls Neuroinflammatory and Antioxidant Activities and Protects Dopaminergic Neurons in Mouse Models of Parkinson’s Disease

Neuroinflammation and oxidative stress underlie the pathogenesis of various neurodegenerative disorders. Here we demonstrate that sodium phenylbutyrate (NaPB), an FDA-approved therapy for reducing plasma ammonia and glutamine in urea cycle disorders, can suppress both proinflammatory molecules and r...

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Detalles Bibliográficos
Autores principales: Roy, Avik, Ghosh, Anamitra, Jana, Arundhati, Liu, Xiaojuan, Brahmachari, Saurav, Gendelman, Howard E., Pahan, Kalipada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377667/
https://www.ncbi.nlm.nih.gov/pubmed/22723850
http://dx.doi.org/10.1371/journal.pone.0038113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377667/
https://www.ncbi.nlm.nih.gov/pubmed/22723850
http://dx.doi.org/10.1371/journal.pone.0038113

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