Paradoxical Lower Serum Triglyceride Levels and Higher Type 2 Diabetes Mellitus Susceptibility in Obese Individuals with the PNPLA3 148M Variant

BACKGROUND: Obesity is highly associated with elevated serum triglycerides, hepatic steatosis and type 2 diabetes (T2D). The I148M (rs738409) genetic variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is known to modulate hepatic triglyceride accumulation, leading to steatosis....

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Detalles Bibliográficos
Autores principales: Palmer, Colin N. A., Maglio, Cristina, Pirazzi, Carlo, Burza, Maria Antonella, Adiels, Martin, Burch, Lindsay, Donnelly, Louise A., Colhoun, Helen, Doney, Alexander S., Dillon, John F., Pearson, Ewan R., McCarthy, Mark, Hattersley, Andrew T., Frayling, Tim, Morris, Andrew D., Peltonen, Markku, Svensson, Per-Arne, Jacobson, Peter, Borén, Jan, Sjöström, Lars, Carlsson, Lena M. S., Romeo, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377675/
https://www.ncbi.nlm.nih.gov/pubmed/22724004
http://dx.doi.org/10.1371/journal.pone.0039362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377675/
https://www.ncbi.nlm.nih.gov/pubmed/22724004
http://dx.doi.org/10.1371/journal.pone.0039362

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