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Mitochondrial DNA Copy Number, but Not Haplogroup, Confers a Genetic Susceptibility to Leprosy in Han Chinese from Southwest China
BACKGROUND: Leprosy is a chronic infectious disease caused by Mycobacterium leprae, an unculturable pathogen with an exceptionally eroded genome. The high level of inactivation of gene function in M. leprae, including many genes in its metabolic pathways, has led to a dependence on host energy produ...
Autores principales: | Wang, Dong, Su, Ling-Yan, Zhang, A-Mei, Li, Yu-Ye, Li, Xiao-An, Chen, Ling-Ling, Long, Heng, Yao, Yong-Gang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377694/ https://www.ncbi.nlm.nih.gov/pubmed/22719964 http://dx.doi.org/10.1371/journal.pone.0038848 |
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