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Essential Role of Cdc42 in Ras-Induced Transformation Revealed by Gene Targeting
The ras proto-oncogene is one of the most frequently mutated genes in human cancer. However, given the prevalence of activating mutations in Ras and its association with aggressive forms of cancer, attempts to therapeutically target aberrant Ras signaling have been largely disappointing. This lack o...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377703/ https://www.ncbi.nlm.nih.gov/pubmed/22719838 http://dx.doi.org/10.1371/journal.pone.0037317 |