Cargando…

Segment-Wise Genome-Wide Association Analysis Identifies a Candidate Region Associated with Schizophrenia in Three Independent Samples

Recent studies suggest that variation in complex disorders (e.g., schizophrenia) is explained by a large number of genetic variants with small effect size (Odds Ratio∼1.05–1.1). The statistical power to detect these genetic variants in Genome Wide Association (GWA) studies with large numbers of case...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gladwin, Thomas E., Derks, Eske M., Rietschel, Marcella, Mattheisen, Manuel, Breuer, René, Schulze, Thomas G., Nöthen, Markus M., Levinson, Douglas, Shi, Jianxin, Gejman, Pablo V., Cichon, Sven, Ophoff, Roel A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377732/ https://www.ncbi.nlm.nih.gov/pubmed/22723893 http://dx.doi.org/10.1371/journal.pone.0038828

Ejemplares similares

Evaluating Historical Candidate Genes for Schizophrenia
por: Farrell, Martilias, et al.
Publicado: (2015)

Investigation of the Genetic Association between Quantitative Measures of Psychosis and Schizophrenia: A Polygenic Risk Score Analysis
por: Derks, Eske M., et al.
Publicado: (2012)

Integrated Pathway-Based Approach Identifies Association between Genomic Regions at CTCF and CACNB2 and Schizophrenia
por: Juraeva, Dilafruz, et al.
Publicado: (2014)

Correction: Investigation of the Genetic Association between Quantitative Measures of Psychosis and Schizophrenia: A Polygenic Risk Score Analysis
por: Derks, Eske M., et al.
Publicado: (2013)

A Genetic Deconstruction of Neurocognitive Traits in Schizophrenia and Bipolar Disorder
por: Fernandes, Carla P. D., et al.
Publicado: (2013)

Copy Number Variants in German Patients with Schizophrenia
por: Priebe, Lutz, et al.
Publicado: (2013)

New findings in the genetics of major psychoses
por: Nöthen, Markus M, et al.
Publicado: (2010)

New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia?
por: Nieratschker, Vanessa, et al.
Publicado: (2010)

Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci
por: Børglum, A D, et al.
Publicado: (2014)

Meta-analysis of genome-wide association data detects a risk locus for major mood disorders on chromosome 3p21.1
por: McMahon, Francis J., et al.
Publicado: (2010)

Genome-wide significant association between a ‘negative mood delusions' dimension in bipolar disorder and genetic variation on chromosome 3q26.1
por: Meier, S, et al.
Publicado: (2012)

Duplications in RB1CC1 are associated with schizophrenia; identification in large European sample sets
por: Degenhardt, F, et al.
Publicado: (2013)

Investigation of manic and euthymic episodes identifies state- and trait-specific gene expression and STAB1 as a new candidate gene for bipolar disorder
por: Witt, S H, et al.
Publicado: (2014)

The Association between Intelligence Scores and Family History of Psychiatric Disorder in Schizophrenia Patients, Their Siblings and Healthy Controls
por: Verweij, Kim H. W., et al.
Publicado: (2013)

Genome-wide association of mood-incongruent psychotic bipolar disorder
por: Goes, F S, et al.
Publicado: (2012)

No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study
por: Johnson, Emma C., et al.
Publicado: (2016)

DCLK1 Variants Are Associated across Schizophrenia and Attention Deficit/Hyperactivity Disorder
por: Håvik, Bjarte, et al.
Publicado: (2012)

Associations between SNPs and immune-related circulating proteins in schizophrenia
por: Chan, Man K., et al.
Publicado: (2017)

Expert and self-assessment of lifetime symptoms and diagnosis of major depressive disorder in large-scale genetic studies in the general population: comparison of a clinical interview and a self-administered checklist
por: Martin, Jessica, et al.
Publicado: (2017)

Gene-Based Analysis of Regionally Enriched Cortical Genes in GWAS Data Sets of Cognitive Traits and Psychiatric Disorders
por: Ersland, Kari M., et al.
Publicado: (2012)

Identification of increased genetic risk scores for schizophrenia in treatment-resistant patients
por: Frank, J, et al.
Publicado: (2015)

Functional impact of a recently identified quantitative trait locus for hippocampal volume with genome-wide support
por: Erk, S, et al.
Publicado: (2013)

The Relationship of DNA Methylation with Age, Gender and Genotype in Twins and Healthy Controls
por: Boks, Marco P., et al.
Publicado: (2009)

Genome-wide association study implicates NDST3 in schizophrenia and bipolar disorder
por: Lencz, Todd, et al.
Publicado: (2013)

Rare SHANK2 variants in schizophrenia
por: Peykov, S, et al.
Publicado: (2015)

Functional neuroimaging effects of recently discovered genetic risk loci for schizophrenia and polygenic risk profile in five RDoC subdomains
por: Erk, S, et al.
Publicado: (2017)

Reduced Anxiety and Depression-Like Behaviours in the Circadian Period Mutant Mouse Afterhours
por: Keers, Robert, et al.
Publicado: (2012)

Replication of functional serotonin receptor type 3A and B variants in bipolar affective disorder: a European multicenter study
por: Hammer, C, et al.
Publicado: (2012)

Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS
por: Wang, Yunpeng, et al.
Publicado: (2016)

Integrative Network-Based Analysis Reveals Gene Networks and Novel Drug Repositioning Candidates for Alzheimer Disease
por: Gerring, Zachary F., et al.
Publicado: (2021)

Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder
por: Schulze, TG, et al.
Publicado: (2008)

Identification of rare variants in KCTD13 at the schizophrenia risk locus 16p11.2
por: Degenhardt, Franziska, et al.
Publicado: (2016)

Neurocognitive Endophenotypes of Schizophrenia and Bipolar Disorder and Possible Associations with FKBP Variant rs3800373
por: Memic, Amra, et al.
Publicado: (2018)

Gene expression of NMDA receptor subunits in the cerebellum of elderly patients with schizophrenia
por: Schmitt, Andrea, et al.
Publicado: (2009)

An analysis of genetically regulated gene expression across multiple tissues implicates novel gene candidates in Alzheimer’s disease
por: Gerring, Zachary F., et al.
Publicado: (2020)

Analysis of the joint effect of SNPs to identify independent loci and allelic heterogeneity in schizophrenia GWAS data
por: Polushina, Tatiana, et al.
Publicado: (2017)

What Cure Models Can Teach us About Genome-Wide Survival Analysis
por: Stringer, Sven, et al.
Publicado: (2015)

A tutorial on conducting genome‐wide association studies: Quality control and statistical analysis
por: Marees, Andries T., et al.
Publicado: (2018)

A Neuregulin-1 schizophrenia susceptibility variant causes perihippocampal fiber tract anomalies in healthy young subjects
por: Nickl-Jockschat, Thomas, et al.
Publicado: (2014)

Health is wisely sharing vulnerability
por: Thomas, Paul
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_gdpsml800a2kncjjglkvd27aed