General Sensitization of Melanoma Cells for TRAIL-Induced Apoptosis by the Potassium Channel Inhibitor TRAM-34 Depends on Release of SMAC

The death ligand TRAIL represents a promising therapeutic strategy for metastatic melanoma, however prevalent and inducible resistance limit its applicability. A new approach is presented here for sensitization to TRAIL. It is based on inhibition of the membrane potassium channel KCa3.1 (IK1), which...

Descripción completa

Detalles Bibliográficos
Autores principales: Quast, Sandra-Annika, Berger, Anja, Buttstädt, Nicole, Friebel, Kristin, Schönherr, Roland, Eberle, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377761/
https://www.ncbi.nlm.nih.gov/pubmed/22723988
http://dx.doi.org/10.1371/journal.pone.0039290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377761/
https://www.ncbi.nlm.nih.gov/pubmed/22723988
http://dx.doi.org/10.1371/journal.pone.0039290

Ejemplares similares