Induced chromosome deletions cause hypersociability and other features of Williams–Beuren syndrome in mice

The neurodevelopmental disorder Williams–Beuren syndrome is caused by spontaneous ∼1.5 Mb deletions comprising 25 genes on human chromosome 7q11.23. To functionally dissect the deletion and identify dosage-sensitive genes, we created two half-deletions of the conserved syntenic region on mouse chrom...

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Detalles Bibliográficos
Autores principales: Li, Hong Hua, Roy, Madhuri, Kuscuoglu, Unsal, Spencer, Corinne M, Halm, Birgit, Harrison, Katharine C, Bayle, Joseph H, Splendore, Alessandra, Ding, Feng, Meltzer, Leslie A, Wright, Elena, Paylor, Richard, Deisseroth, Karl, Francke, Uta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378107/
https://www.ncbi.nlm.nih.gov/pubmed/20049703
http://dx.doi.org/10.1002/emmm.200900003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378107/
https://www.ncbi.nlm.nih.gov/pubmed/20049703
http://dx.doi.org/10.1002/emmm.200900003

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