Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

Mutations of the mitochondrial PTEN (phosphatase and tensin homologue)-induced kinase1 (PINK1) are important causes of recessive Parkinson disease (PD). Studies on loss of function and overexpression implicate PINK1 in apoptosis, abnormal mitochondrial morphology, impaired dopamine release and motor...

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Detalles Bibliográficos
Autores principales: Morais, Vanessa A, Verstreken, Patrik, Roethig, Anne, Smet, Joél, Snellinx, An, Vanbrabant, Mieke, Haddad, Dominik, Frezza, Christian, Mandemakers, Wim, Vogt-Weisenhorn, Daniela, Van Coster, Rudy, Wurst, Wolfgang, Scorrano, Luca, De Strooper, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378121/
https://www.ncbi.nlm.nih.gov/pubmed/20049710
http://dx.doi.org/10.1002/emmm.200900006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378121/
https://www.ncbi.nlm.nih.gov/pubmed/20049710
http://dx.doi.org/10.1002/emmm.200900006

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