Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2

Mutations in the MSH2 gene predispose to a number of tumourigenic conditions, including hereditary non-polyposis colon cancer (HNPCC). MSH2 encodes a protein in the mismatch repair (MMR) pathway which is involved in the removal of mispairs originating during replication or from damaged DNA. To ident...

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Detalles Bibliográficos
Autores principales: Martin, Sarah A, McCarthy, Afshan, Barber, Louise J, Burgess, Darren J, Parry, Suzanne, Lord, Christopher J, Ashworth, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2009
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378145/
https://www.ncbi.nlm.nih.gov/pubmed/20049736
http://dx.doi.org/10.1002/emmm.200900040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378145/
https://www.ncbi.nlm.nih.gov/pubmed/20049736
http://dx.doi.org/10.1002/emmm.200900040

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