Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

The tumour suppressor gene, phosphatase and tensin homolog (PTEN), is one of the most commonly mutated genes in human cancers. Recent evidence suggests that PTEN is important for the maintenance of genome stability. Here, we show that PTEN deficiency causes a homologous recombination (HR) defect in...

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Detalles Bibliográficos
Autores principales: Mendes-Pereira, Ana M, Martin, Sarah A, Brough, Rachel, McCarthy, Afshan, Taylor, Jessica R, Kim, Jung-Sik, Waldman, Todd, Lord, Christopher J, Ashworth, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2009
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378149/
https://www.ncbi.nlm.nih.gov/pubmed/20049735
http://dx.doi.org/10.1002/emmm.200900041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378149/
https://www.ncbi.nlm.nih.gov/pubmed/20049735
http://dx.doi.org/10.1002/emmm.200900041

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