Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases

Somatic missense mutations in PIK3CA, which encodes the p110α catalytic subunit of phosphoinositide 3-kinases (PI3Ks), occur frequently in human cancers. Activating mutations spread across multiple domains, some of which are located at inhibitory contact sites formed with the regulatory subunit p85α...

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Detalles Bibliográficos
Autores principales: Hon, Wai-Ching, Berndt, Alex, Williams, Roger L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378484/
https://www.ncbi.nlm.nih.gov/pubmed/22120714
http://dx.doi.org/10.1038/onc.2011.532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378484/
https://www.ncbi.nlm.nih.gov/pubmed/22120714
http://dx.doi.org/10.1038/onc.2011.532

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