Small Heat Shock Proteins Potentiate Amyloid Dissolution by Protein Disaggregases from Yeast and Humans

How small heat shock proteins (sHsps) might empower proteostasis networks to control beneficial prions or disassemble pathological amyloid is unknown. Here, we establish that yeast sHsps, Hsp26 and Hsp42, inhibit prionogenesis by the [PSI (+)] prion protein, Sup35, via distinct and synergistic mecha...

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Detalles Bibliográficos
Autores principales: Duennwald, Martin L., Echeverria, AnaLisa, Shorter, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378601/
https://www.ncbi.nlm.nih.gov/pubmed/22723742
http://dx.doi.org/10.1371/journal.pbio.1001346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378601/
https://www.ncbi.nlm.nih.gov/pubmed/22723742
http://dx.doi.org/10.1371/journal.pbio.1001346

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