Role of Hedgehog signalling at the transition from double-positive to single-positive thymocyte

In the thymus, developing T cells receive signals that determine lineage choice, specificity, MHC restriction and tolerance to self-antigen. One way in which thymocytes receive instruction is by secretion of Sonic hedgehog (Shh) from thymic epithelial cells. We have previously shown that Hedgehog (H...

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Detalles Bibliográficos
Autores principales: Furmanski, Anna L, Saldana, Jose Ignacio, Rowbotham, Nicola J, Ross, Susan E, Crompton, Tessa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2012
Materias:
Molecular Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378705/
https://www.ncbi.nlm.nih.gov/pubmed/22101858
http://dx.doi.org/10.1002/eji.201141758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378705/
https://www.ncbi.nlm.nih.gov/pubmed/22101858
http://dx.doi.org/10.1002/eji.201141758

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