Summarizing and correcting the GC content bias in high-throughput sequencing

GC content bias describes the dependence between fragment count (read coverage) and GC content found in Illumina sequencing data. This bias can dominate the signal of interest for analyses that focus on measuring fragment abundance within a genome, such as copy number estimation (DNA-seq). The bias...

Descripción completa

Detalles Bibliográficos
Autores principales: Benjamini, Yuval, Speed, Terence P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378858/
https://www.ncbi.nlm.nih.gov/pubmed/22323520
http://dx.doi.org/10.1093/nar/gks001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378858/
https://www.ncbi.nlm.nih.gov/pubmed/22323520
http://dx.doi.org/10.1093/nar/gks001

Ejemplares similares