RNA folding with soft constraints: reconciliation of probing data and thermodynamic secondary structure prediction

Thermodynamic folding algorithms and structure probing experiments are commonly used to determine the secondary structure of RNAs. Here we propose a formal framework to reconcile information from both prediction algorithms and probing experiments. The thermodynamic energy parameters are adjusted usi...

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Detalles Bibliográficos
Autores principales: Washietl, Stefan, Hofacker, Ivo L., Stadler, Peter F., Kellis, Manolis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378861/
https://www.ncbi.nlm.nih.gov/pubmed/22287623
http://dx.doi.org/10.1093/nar/gks009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378861/
https://www.ncbi.nlm.nih.gov/pubmed/22287623
http://dx.doi.org/10.1093/nar/gks009

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