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RNA folding with soft constraints: reconciliation of probing data and thermodynamic secondary structure prediction
Thermodynamic folding algorithms and structure probing experiments are commonly used to determine the secondary structure of RNAs. Here we propose a formal framework to reconcile information from both prediction algorithms and probing experiments. The thermodynamic energy parameters are adjusted usi...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378861/ https://www.ncbi.nlm.nih.gov/pubmed/22287623 http://dx.doi.org/10.1093/nar/gks009 |