In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important

Small interfering RNAs (siRNAs) are promising new active compounds in gene medicine but the induction of non-specific immune responses following their delivery continues to be a serious problem. With the purpose of avoiding such effects chemically modified siRNAs are tested in screening assay but of...

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Detalles Bibliográficos
Autores principales: Schyth, Brian Dall, Bramsen, Jesper Bertram, Pakula, Malgorzata Maria, Larashati, Sekar, Kjems, Jørgen, Wengel, Jesper, Lorenzen, Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378874/
https://www.ncbi.nlm.nih.gov/pubmed/22287630
http://dx.doi.org/10.1093/nar/gks033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378874/
https://www.ncbi.nlm.nih.gov/pubmed/22287630
http://dx.doi.org/10.1093/nar/gks033

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