Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia-telangiectasia

Ataxia-telangiectasia (A-T) is a neurodegenerative disease caused by mutation of the Atm gene. Here we report that ATM-deficiency causes nuclear accumulation of histone deacetylase 4 (HDAC4) in neurons and promotes neurodegeneration. Nuclear HDAC4 binds to chromatin as well as to MEF2A and CREB, lea...

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Detalles Bibliográficos
Autores principales: Li, Jiali, Chen, Jianmin, Ricupero, Christopher L., Hart, Ronald P, Schwartz, Melanie S., Kusnecov, Alexander, Herrup, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378917/
https://www.ncbi.nlm.nih.gov/pubmed/22466704
http://dx.doi.org/10.1038/nm.2709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378917/
https://www.ncbi.nlm.nih.gov/pubmed/22466704
http://dx.doi.org/10.1038/nm.2709

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