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Oxidative DNA Damage in Neurons: Implication of Ku in Neuronal Homeostasis and Survival
Oxidative DNA damage is produced by reactive oxygen species (ROS) which are generated by exogenous and endogenous sources and continuously challenge the cell. One of the most severe DNA lesions is the double-strand break (DSB), which is mainly repaired by nonhomologous end joining (NHEJ) pathway in...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Hindawi Publishing Corporation
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378965/ https://www.ncbi.nlm.nih.gov/pubmed/22737170 http://dx.doi.org/10.1155/2012/752420 |