Binding of Gemini Bisbenzimidazole Drugs with Human Telomeric G-Quadruplex Dimers: Effect of the Spacer in the Design of Potent Telomerase Inhibitors

The study of anticancer agents that act via stabilization of telomeric G-quadruplex DNA (G4DNA) is important because such agents often inhibit telomerase activity. Several types of G4DNA binding ligands are known. In these studies, the target structures often involve a single G4 DNA unit formed by s...

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Detalles Bibliográficos
Autores principales: Paul, Ananya, Jain, Akash K., Misra, Santosh K., Maji, Basudeb, Muniyappa, K., Bhattacharya, Santanu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380826/
https://www.ncbi.nlm.nih.gov/pubmed/22737240
http://dx.doi.org/10.1371/journal.pone.0039467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380826/
https://www.ncbi.nlm.nih.gov/pubmed/22737240
http://dx.doi.org/10.1371/journal.pone.0039467

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