Cross-Regulation of Protein Stability by p53 and Nuclear Receptor SHP

We report here a novel interplay between tumor suppressor p53 and nuclear receptor SHP that controls p53 and SHP stability. Overexpression of p53 causes rapid SHP protein degradation, which does not require the presence of Mdm2 and is mediated by the proteosome pathway. Overexpressing SHP alone does...

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Detalles Bibliográficos
Autores principales: Yang, Zhihong, Zhang, Yuxia, Kemper, Jongsook Kim, Wang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380837/
https://www.ncbi.nlm.nih.gov/pubmed/22737255
http://dx.doi.org/10.1371/journal.pone.0039789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380837/
https://www.ncbi.nlm.nih.gov/pubmed/22737255
http://dx.doi.org/10.1371/journal.pone.0039789

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