Doxycycline Stabilizes Vulnerable Plaque via Inhibiting Matrix Metalloproteinases and Attenuating Inflammation in Rabbits

Enhanced matrix metalloproteinases (MMPs) activity is implicated in the process of atherosclerotic plaque instability. We hypothesized that doxycycline, a broad MMPs inhibitor, was as effective as simvastatin in reducing the incidence of plaque disruption. Thirty rabbits underwent aortic balloon inj...

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Detalles Bibliográficos
Autores principales: Dong, Mei, Zhong, Lin, Chen, Wen Qiang, Ji, Xiao Ping, Zhang, Mei, Zhao, Yu Xia, Li, Li, Yao, Gui Hua, Zhang, Peng Fei, Zhang, Cheng, Zhang, Lei, Zhang, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380900/
https://www.ncbi.nlm.nih.gov/pubmed/22737253
http://dx.doi.org/10.1371/journal.pone.0039695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380900/
https://www.ncbi.nlm.nih.gov/pubmed/22737253
http://dx.doi.org/10.1371/journal.pone.0039695

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