Cargando…

Doxycycline Stabilizes Vulnerable Plaque via Inhibiting Matrix Metalloproteinases and Attenuating Inflammation in Rabbits

Enhanced matrix metalloproteinases (MMPs) activity is implicated in the process of atherosclerotic plaque instability. We hypothesized that doxycycline, a broad MMPs inhibitor, was as effective as simvastatin in reducing the incidence of plaque disruption. Thirty rabbits underwent aortic balloon inj...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dong, Mei, Zhong, Lin, Chen, Wen Qiang, Ji, Xiao Ping, Zhang, Mei, Zhao, Yu Xia, Li, Li, Yao, Gui Hua, Zhang, Peng Fei, Zhang, Cheng, Zhang, Lei, Zhang, Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380900/ https://www.ncbi.nlm.nih.gov/pubmed/22737253 http://dx.doi.org/10.1371/journal.pone.0039695

Ejemplares similares

Specific Matrix Metalloproteinases Play Different Roles in Intraplaque Angiogenesis and Plaque Instability in Rabbits
por: Liu, Xiao Qiong, et al.
Publicado: (2014)

Chinese Herbal Cardiotonic Pill Stabilizes Vulnerable Plaques in Rabbits by Decreasing the Expression of Adhesion Molecules
por: Chen, Liang, et al.
Publicado: (2016)

Dominant-negative mutation of monocyte chemoattractant protein-1 prevents vulnerable plaques from rupture in rabbits independent of serum lipid levels
por: Zhong, Lin, et al.
Publicado: (2008)

Multidimensional Contribution of Matrix Metalloproteinases to Atherosclerotic Plaque Vulnerability: Multiple Mechanisms of Inhibition to Promote Stability
por: Ruddy, Jean Marie, et al.
Publicado: (2016)

Multispectral Optoacoustic Tomography of Matrix Metalloproteinase Activity in Vulnerable Human Carotid Plaques
por: Razansky, Daniel, et al.
Publicado: (2011)

Blocking human fear memory with the matrix metalloproteinase inhibitor doxycycline
por: Bach, D R, et al.
Publicado: (2017)

Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice
por: Jung, Jae-Joon, et al.
Publicado: (2016)

Doxycycline Therapy for Abdominal Aortic Aneurysm: Inhibitory Effect on Matrix Metalloproteinases
por: Paghdar, Smit, et al.
Publicado: (2021)

Effect of the Matrix Metalloproteinase Inhibitor Doxycycline on Human Trace Fear Memory
por: Wehrli, Jelena M., et al.
Publicado: (2023)

Doxycycline inhibits leukemic cell migration via inhibition of matrix metalloproteinases and phosphorylation of focal adhesion kinase
por: WANG, CHUNHUAI, et al.
Publicado: (2015)

Effects of Serum Lipid Smoothness on the Progression and Vulnerability of Atherosclerotic Plaques in Rabbits
por: Zou, Xiao, et al.
Publicado: (2014)

An alternative therapy for idiopathic pulmonary fibrosis by doxycycline through matrix metalloproteinase inhibition
por: Mishra, Amartya, et al.
Publicado: (2011)

The Role of Matrix Metalloproteinase-9 in Atherosclerotic Plaque Instability
por: Li, Tiewei, et al.
Publicado: (2020)

Colchicine reduces atherosclerotic plaque vulnerability in rabbits
por: Roubille, François, et al.
Publicado: (2021)

Matrix Metalloproteinases as Biomarkers of Atherosclerotic Plaque Instability
por: Olejarz, Wioletta, et al.
Publicado: (2020)

Bionic Microbubble Neutrophil Composite for Inflammation-Responsive Atherosclerotic Vulnerable Plaque Pluripotent Intervention
por: Liu, Fangfang, et al.
Publicado: (2022)

Impact of PCSK9 Inhibition on Proinflammatory Cytokines and Matrix Metalloproteinases Release in Patients with Mixed Hyperlipidemia and Vulnerable Atherosclerotic Plaque
por: Basiak, Marcin, et al.
Publicado: (2022)

Identifying Vulnerable Atherosclerotic Plaque in Rabbits Using DMSA-USPIO Enhanced Magnetic Resonance Imaging to Investigate the Effect of Atorvastatin
por: Qi, Chunmei, et al.
Publicado: (2015)

Levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 are related to cardiopulmonary injury in fetal inflammatory response syndrome
por: Yan, Yiwei, et al.
Publicado: (2020)

The Immunologic Injury Composite with Balloon Injury Leads to Dyslipidemia: A Robust Rabbit Model of Human Atherosclerosis and Vulnerable Plaque
por: Zhang, Guangyin, et al.
Publicado: (2012)

Procyanidins attenuate neuropathic pain by suppressing matrix metalloproteinase-9/2
por: Pan, Cailong, et al.
Publicado: (2018)

Role of sirtuins in attenuating plaque vulnerability in atherosclerosis
por: Velpuri, Prathosh, et al.
Publicado: (2023)

Thermal stability of human matrix metalloproteinases
por: Meraz-Cruz, Noemi, et al.
Publicado: (2020)

Desipramine enhances the stability of atherosclerotic plaque in rabbits monitored with molecular imaging
por: Zhao, Min, et al.
Publicado: (2023)

Effect of doxycycline and meloxicam on cytokines, brain-derived neurotrophic factor, matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-3 and cyclooxygenase-2 in brain
por: Er, Ayse, et al.
Publicado: (2020)

Tongxinluo May Alleviate Inflammation and Improve the Stability of Atherosclerotic Plaques by Changing the Intestinal Flora
por: Qi, Yan, et al.
Publicado: (2022)

Imbalance of matrix metalloproteinase-9 and matrix metalloproteinase tissue inhibitor-1 may contribute to hemorrhage in cerebellar arteriovenous malformations☆
por: Di, Fei, et al.
Publicado: (2012)

Matrix Metalloproteinases as Regulators of Periodontal Inflammation
por: Franco, Cavalla, et al.
Publicado: (2017)

Local Gene Silencing of Monocyte Chemoattractant Protein-1 Prevents Vulnerable Plaque Disruption in Apolipoprotein E-Knockout Mice
por: Liu, Xiao Ling, et al.
Publicado: (2012)

Threat Memory Reminder Under Matrix Metalloproteinase 9 Inhibitor Doxycycline Globally Reduces Subsequent Memory Plasticity
por: Bach, Dominik R., et al.
Publicado: (2019)

Immune-Mediated Inflammation in Vulnerable Atherosclerotic Plaques
por: Mangge, Harald, et al.
Publicado: (2019)

Altered Matrix Metalloproteinases Expression in Placenta from Patients with Gestational Diabetes Mellitus
por: Ding, Rong, et al.
Publicado: (2018)

Melatonin attenuates angiotensin II-induced abdominal aortic aneurysm through the down-regulation of matrix metalloproteinases
por: Kong, Jing, et al.
Publicado: (2017)

Birt-Hogg-Dubé syndrome: metalloproteinase activity and response to doxycycline
por: Pimenta, Suzana Pinheiro, et al.
Publicado: (2012)

Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Inflammation and Fibrosis of Skeletal Muscles
por: Alameddine, Hala S., et al.
Publicado: (2016)

Expression of matrix Metalloproteinases-2 and aquaporin-1 in corneoscleral junction after angle-closure in rabbits
por: Jiang, Yaqin, et al.
Publicado: (2019)

Mesenchymal Stem Cells Stabilize Atherosclerotic Vulnerable Plaque by Anti-Inflammatory Properties
por: Wang, Shuang-shuang, et al.
Publicado: (2015)

Association of Lipoprotein-Associated Phospholipase A(2) with Characteristics of Vulnerable Coronary Atherosclerotic Plaques
por: Liu, Yu-Sheng, et al.
Publicado: (2011)

Expression of Matrix Metalloproteinase-2, Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1, and Changes in Alveolar Septa in Patients with Chronic Obstructive Pulmonary Disease
por: Zhang, Yongxiang, et al.
Publicado: (2020)

Early identification of carotid vulnerable plaque in asymptomatic patients
por: Jiao, Yungen, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_hm9m6feq04p92q1c3oa1mrirj1