M-opsin protein degradation is inhibited by MG-132 in Rpe65(−/−) retinal explant culture

PURPOSE: The 65 kDa retinal pigment epithelium-specific protein, RPE65, is an essential enzyme for 11-cis-retinal synthesis in the eye. Mutations of the RPE65 gene in humans result in severe vision loss, and Rpe65(−/−) mice show early cone photoreceptor degeneration. We used an explant culture syste...

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Detalles Bibliográficos
Autores principales: Sato, Kota, Ozaki, Taku, Ishiguro, Sei-ichi, Nakazawa, Mitsuru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380917/
https://www.ncbi.nlm.nih.gov/pubmed/22736942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380917/
https://www.ncbi.nlm.nih.gov/pubmed/22736942

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