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Conformational Basis for Asymmetric Seeding Barrier in Filaments of Three- and Four-Repeat Tau
[Image: see text] Tau pathology in Alzheimer’s disease is intimately linked to the deposition of proteinacious filaments, which akin to infectious prions, have been proposed to spread via seeded conversion. Here we use double electron–electron resonance (DEER) spectroscopy in combination with extens...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381011/ https://www.ncbi.nlm.nih.gov/pubmed/22656332 http://dx.doi.org/10.1021/ja303498q |