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Conformational Basis for Asymmetric Seeding Barrier in Filaments of Three- and Four-Repeat Tau

[Image: see text] Tau pathology in Alzheimer’s disease is intimately linked to the deposition of proteinacious filaments, which akin to infectious prions, have been proposed to spread via seeded conversion. Here we use double electron–electron resonance (DEER) spectroscopy in combination with extens...

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Detalles Bibliográficos
Autores principales:	Siddiqua, Ayisha, Luo, Yin, Meyer, Virginia, Swanson, Michael A., Yu, Xiang, Wei, Guanghong, Zheng, Jie, Eaton, Gareth R., Ma, Buyong, Nussinov, Ruth, Eaton, Sandra S., Margittai, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2012
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381011/ https://www.ncbi.nlm.nih.gov/pubmed/22656332 http://dx.doi.org/10.1021/ja303498q

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