5-Aza-2′-deoxycytidine-induced genome rearrangements are mediated by DNMT1

Observations that genome-wide DNA hypomethylation induces genomic instability and tumors in animals caution against the indiscriminate use of demethylating agents, such as 5-aza-2′-deoxycytidine (5-Aza-dC). Using primary mouse embryonic fibroblasts harboring a lacZ mutational reporter construct that...

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Detalles Bibliográficos
Autores principales: Maslov, Alexander Y., Lee, Moonsook, Gundry, Michael, Gravina, Silvia, Strogonova, Nadezhda, Tazearslan, Cagdas, Bendebury, Anastasia, Suh, Yousin, Vijg, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381073/
https://www.ncbi.nlm.nih.gov/pubmed/22349820
http://dx.doi.org/10.1038/onc.2012.9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381073/
https://www.ncbi.nlm.nih.gov/pubmed/22349820
http://dx.doi.org/10.1038/onc.2012.9

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