Cargando…

5-Aza-2′-deoxycytidine-induced genome rearrangements are mediated by DNMT1

Observations that genome-wide DNA hypomethylation induces genomic instability and tumors in animals caution against the indiscriminate use of demethylating agents, such as 5-aza-2′-deoxycytidine (5-Aza-dC). Using primary mouse embryonic fibroblasts harboring a lacZ mutational reporter construct that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maslov, Alexander Y., Lee, Moonsook, Gundry, Michael, Gravina, Silvia, Strogonova, Nadezhda, Tazearslan, Cagdas, Bendebury, Anastasia, Suh, Yousin, Vijg, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381073/ https://www.ncbi.nlm.nih.gov/pubmed/22349820 http://dx.doi.org/10.1038/onc.2012.9

Ejemplares similares

AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine
por: Tsai, Chiou-Tsun, et al.
Publicado: (2013)

Targeting of 5-aza-2′-deoxycytidine residues by chromatin-associated DNMT1 induces proteasomal degradation of the free enzyme
por: Patel, Katan, et al.
Publicado: (2010)

Aza-deoxycytidine induces apoptosis or differentiation via DNMT3B and targets embryonal carcinoma cells but not their differentiated derivatives
por: Wongtrakoongate, P, et al.
Publicado: (2014)

Identification and functional validation of an enhancer variant in the 9p21.3 locus associated with glaucoma risk and elevated expression of p16(INK4a)
por: Zhu, Yizhou, et al.
Publicado: (2023)

Identification and functional validation of an enhancer variant in the 9p21.3 locus associated with glaucoma risk and elevated expression of p16(INK4a)
por: Zhu, Yizhou, et al.
Publicado: (2023)

Age- and Tissue-Specific Expression of Senescence Biomarkers in Mice
por: Hudgins, Adam D., et al.
Publicado: (2018)

The epigenetic impact of suberohydroxamic acid and 5-Aza-2′-deoxycytidine on DNMT3B expression in myeloma cell lines differing in IL-6 expression
por: Smesny Trtkova, Katerina, et al.
Publicado: (2022)

Concurrent analysis of genome and transcriptome in one single cell
por: Heid, Johanna, et al.
Publicado: (2023)

The antileukaemic activity of 5-Aza-2 deoxycytidine (Aza-dC) in patients with relapsed and resistant leukaemia.
por: Richel, D. J., et al.
Publicado: (1991)

5-Aza-2′-deoxycytidine stress response and apoptosis in prostate cancer
por: Patra, Aditi, et al.
Publicado: (2011)

Epigenetic regulation of the circadian clock: role of 5-aza-2′-deoxycytidine
por: Tomita, Tatsunosuke, et al.
Publicado: (2017)

Effect of Sulforaphane and 5-Aza-2’-Deoxycytidine on Melanoma Cell Growth
por: Chiang, Tung-chin, et al.
Publicado: (2019)

Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan
por: Zhang, Lei, et al.
Publicado: (2019)

Importance of dose-schedule of 5-aza-2'-deoxycytidine for epigenetic therapy of cancer
por: Lemaire, Maryse, et al.
Publicado: (2008)

Anticancer efficacy of cisplatin and trichostatin A or 5-aza-2′-deoxycytidine on ovarian cancer
por: Meng, F, et al.
Publicado: (2013)

Sequential treatment with 5‐aza‐2′‐deoxycytidine and deacetylase inhibitors reactivates HIV‐1
por: Bouchat, Sophie, et al.
Publicado: (2015)

DNA demethylation caused by 5-Aza-2′-deoxycytidine induces mitotic alterations and aneuploidy
por: Costa, Giuseppe, et al.
Publicado: (2016)

Induction of MAGE Genes in Lymphoid Cells by the Demethylating Agent 5‐Aza‐2′‐deoxycytidine
por: Shichijo, Shigeki, et al.
Publicado: (1996)

Hydralazine Sensitizes to the Antifibrotic Effect of 5-Aza-2′-deoxycytidine in Hepatic Stellate Cells
por: Asada, Kiyoshi, et al.
Publicado: (2020)

Effects of 5-aza-2´-deoxycytidine on primary human chondrocytes from osteoarthritic patients
por: Kadler, Shirin, et al.
Publicado: (2020)

The Methylation Inhibitor 5-Aza-2′-Deoxycytidine Induces Genome-Wide Hypomethylation in Rice
por: Liu, Shuo, et al.
Publicado: (2022)

Bleomycin-induced genome structural variations in normal, non-tumor cells
por: Quispe-Tintaya, Wilber, et al.
Publicado: (2018)

Accurate identification of single nucleotide variants in whole genome amplified single cells
por: Dong, Xiao, et al.
Publicado: (2017)

FOXO3a acts to suppress DNA double‐strand break‐induced mutations
por: White, Ryan R., et al.
Publicado: (2020)

Single-molecule, quantitative detection of low-abundance somatic mutations by high-throughput sequencing
por: Maslov, Alexander Y., et al.
Publicado: (2022)

Age-related somatic mutations in the cancer genome
por: Milholland, Brandon, et al.
Publicado: (2015)

Comparison of the antileukaemic activity of 5 aza-2-deoxycytidine and arabinofuranosyl-cytosine in rats with myelocytic leukaemia.
por: Richel, D. J., et al.
Publicado: (1988)

The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions
por: Orta, Manuel Luis, et al.
Publicado: (2014)

Isoform switching and exon skipping induced by the DNA methylation inhibitor 5-Aza-2′-deoxycytidine
por: Ding, Xiao-Lei, et al.
Publicado: (2016)

Synergistic activity of everolimus and 5‐aza‐2′‐deoxycytidine in medullary thyroid carcinoma cell lines
por: Vitale, Giovanni, et al.
Publicado: (2017)

Effect of Decitabine (5-aza-2ˈ-deoxycytidine, 5-aza-CdR) in Comparison with Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) on DNMT1, DNMT3a and DNMT3b, HDAC 1-3, SOCS 1, SOCS 3, JAK2, and STAT3 Gene Expression in Hepatocellular Carcinoma HLE and LCL-PI 11 Cell Lines
por: Sanaei, Masumeh, et al.
Publicado: (2021)

Genetic evidence for common pathways in human age-related diseases
por: Johnson, Simon C, et al.
Publicado: (2015)

Quantitative detection of low-abundance somatic structural variants in normal cells by high throughput sequencing
por: Quispe-Tintaya, Wilber, et al.
Publicado: (2016)

Microwave Accelerated Aza-Claisen Rearrangement
por: Gajdošíková, Eva, et al.
Publicado: (2008)

PBRM1 Deficiency Sensitizes Renal Cancer Cells to DNMT Inhibitor 5-Fluoro-2’-Deoxycytidine
por: Gu, Di, et al.
Publicado: (2022)

5-Azacytidine and 5-aza-2'-deoxycytidine behave as different antineoplastic agents in B16 melanoma.
por: Cortvrindt, R., et al.
Publicado: (1987)

Epigenetic Therapy of Non-Small Cell Lung Cancer Using Decitabine (5-Aza-2′-Deoxycytidine)
por: Momparler, Richard L.
Publicado: (2013)

A Perspective on the Comparative Antileukemic Activity of 5-Aza-2′-deoxycytidine (Decitabine) and 5-Azacytidine (Vidaza)
por: Momparler, Richard L.
Publicado: (2012)

Gene expression profiling of the synergy of 5-aza-2(′)-deoxycytidine and paclitaxel against renal cell carcinoma
por: Han, Tiandong, et al.
Publicado: (2012)

Antineoplastic activity of the DNA methyltransferase inhibitor 5-aza-2′-deoxycytidine in anaplastic large cell lymphoma
por: Hassler, Melanie R., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_7l6sm7al4k7m6nnae9lq5fqu25