siRNA-optimized Modifications for Enhanced In Vivo Activity

Current modifications used in small interfering RNAs (siRNAs), such as 2'-methoxy (2'-OMe) and 2'-fluoro (2'-F), improve stability, specificity or immunogenic properties but do not improve potency. These modifications were previously designed for use in antisense and not siRNA. W...

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Detalles Bibliográficos
Autores principales: Kenski, Denise M, Butora, Gabor, Willingham, Aarron T, Cooper, Abby J, Fu, Wenlang, Qi, Ning, Soriano, Ferdie, Davies, Ian W, Flanagan, W Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381598/
https://www.ncbi.nlm.nih.gov/pubmed/23344622
http://dx.doi.org/10.1038/mtna.2011.4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381598/
https://www.ncbi.nlm.nih.gov/pubmed/23344622
http://dx.doi.org/10.1038/mtna.2011.4

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