Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells

Cell cycle checkpoints ensure genome integrity and are frequently compromised in human cancers. A therapeutic strategy being explored takes advantage of checkpoint defects in p53 deficient tumors in order to sensitize them to DNA damaging agents by eliminating Chk1-mediated checkpoint responses. Usi...

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Detalles Bibliográficos
Autores principales: Origanti, Sofia, Cai, Shi-rong, Munir, Amir Z., White, Lynn S., Piwnica-Worms, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381958/
https://www.ncbi.nlm.nih.gov/pubmed/22430210
http://dx.doi.org/10.1038/onc.2012.84

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381958/
https://www.ncbi.nlm.nih.gov/pubmed/22430210
http://dx.doi.org/10.1038/onc.2012.84

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