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Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells
Cell cycle checkpoints ensure genome integrity and are frequently compromised in human cancers. A therapeutic strategy being explored takes advantage of checkpoint defects in p53 deficient tumors in order to sensitize them to DNA damaging agents by eliminating Chk1-mediated checkpoint responses. Usi...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381958/ https://www.ncbi.nlm.nih.gov/pubmed/22430210 http://dx.doi.org/10.1038/onc.2012.84 |