Mitochondrionopathy Phenotype in Doxorubicin-Treated Wistar Rats Depends on Treatment Protocol and Is Cardiac-Specific

Although doxorubicin (DOX) is a very effective antineoplastic agent, its clinical use is limited by a dose-dependent, persistent and cumulative cardiotoxicity, whose mechanism remains to be elucidated. Previous works in animal models have failed to use a multi-organ approach to demonstrate that DOX-...

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Detalles Bibliográficos
Autores principales: Pereira, Gonçalo C., Pereira, Susana P., Pereira, Claudia V., Lumini, José A., Magalhães, José, Ascensão, António, Santos, Maria S., Moreno, António J., Oliveira, Paulo J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382146/
https://www.ncbi.nlm.nih.gov/pubmed/22745682
http://dx.doi.org/10.1371/journal.pone.0038867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382146/
https://www.ncbi.nlm.nih.gov/pubmed/22745682
http://dx.doi.org/10.1371/journal.pone.0038867

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