Investigation of D(2) Receptor–Agonist Interactions Using a Combination of Pharmacophore and Receptor Homology Modeling

A combined modeling approach was used to identify structural factors that underlie the structure–activity relationships (SARs) of full dopamine D(2) receptor agonists and structurally similar inactive compounds. A 3D structural model of the dopamine D(2) receptor was constructed, with the agonist (−...

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Detalles Bibliográficos
Autores principales: Malo, Marcus, Brive, Lars, Luthman, Kristina, Svensson, Peder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2012
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382189/
https://www.ncbi.nlm.nih.gov/pubmed/22315215
http://dx.doi.org/10.1002/cmdc.201100545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382189/
https://www.ncbi.nlm.nih.gov/pubmed/22315215
http://dx.doi.org/10.1002/cmdc.201100545

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