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Investigation of D(2) Receptor–Agonist Interactions Using a Combination of Pharmacophore and Receptor Homology Modeling

A combined modeling approach was used to identify structural factors that underlie the structure–activity relationships (SARs) of full dopamine D(2) receptor agonists and structurally similar inactive compounds. A 3D structural model of the dopamine D(2) receptor was constructed, with the agonist (−...

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Detalles Bibliográficos
Autores principales:	Malo, Marcus, Brive, Lars, Luthman, Kristina, Svensson, Peder
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2012
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382189/ https://www.ncbi.nlm.nih.gov/pubmed/22315215 http://dx.doi.org/10.1002/cmdc.201100545

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